Male Contraceptive Methods in Development

Journal :

Reproductive Health / PMC (2025) · 2025

Congress synthesis: reviews advanced hormonal gel nearing phase IIb and modified androgens in early testing; proposes strategic roadmap for male contraception R&D.

Journal :

Journal of Clinical Endocrinology & Metabolism (2024) · 2024

Overview of agents in development (DMAU, 11β-MNTDC, others), plus status of the NES/T gel efficacy trial; maps hormonal & nonhormonal pipelines.

Journal :

Pharmacological Reviews (2024) · 2024

Proposal of development strategies for nonhormonal male contraception, learning from past failures and focusing on translational pathways.

Journal :

American Society / European Acad of Andrology Review (2024) · 2024

Examines emerging strategies to inhibit sperm production or function, from hormonal to nonhormonal, focusing on those in preclinical or early clinical stages.

Journal :

Basic & Clinical Andrology (2023) · 2023

Narrative review: two hormonal male contraceptive methods in phase II trials; large trial of Nestorone+Testosterone gel underway with >460 couples enrolled.

Journal :

Journal of Clinical Medicine (2025) · 2025

Review summarizing achievements, challenges and future directions in male hormonal contraception — suppression strategies, reversibility, side effect profiles.

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